Research

Hypochlorous Acid: An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm, and Wound Healing Potency.

Sakarya, S., Gunay, N., Karakulak, M., Ozturk, B., & Ertugrul, B. (2024). 26(12), 342-350

https://pubmed.ncbi.nlm.nih.gov/25785777/

Hypochlorous Acid as a Potential Wound Care Agent: Part 1 Stabilized Hypochlorous Acid: A Component of the Inorganic Armamentarium of Innate Immunity.

Wang, L., Bassiri, M., Najafi, R., Najafi, K., Yang, J., Khosrovi, B., Hwong, W., Barati, E., Belisle, B., Celeri, C., & Robson, M.C. (2007)
Journal of Burns and Wounds, 6, e5.

https://pubmed.ncbi.nlm.nih.gov/17492050/

The Immediate and Delayed Post-Debridement Effects on Tissue Bacterial Bioburden of Hypochlorous Acid Solutions Compared to Saline and Povidone-Iodine Irrigation in an Infected Diabetic Foot Ulcer Model.

Hiebert, J.M., Robson, M.C. (2016).
ePlasty, 16, e32

https://pmc.ncbi.nlm.nih.gov/articles/PMC5259692/

Effects of Stabilized Hypochlorous Acid on Re-epithelialization and Bacterial Bioburden in Acute Wounds: A Randomized Controlled Trial in Healthy Volunteers.

Burian, E.A., Sabah, L., Kirketerp-Moller, K., Gundersen, G., & Agren, M.S. (2022)
Acta Dermato-Venereologica, 102, adv00727.

https://pubmed.ncbi.nlm.nih.gov/35578822/

Topical stabilized hypochlorous acid: The future gold standard for wound care and scar management in dermatologic and plastic surgery procedures.

Gold, M.H., Andriessen, A., Bhatia, A.C., Bitter, P. Jr., Chilukuri, S., Cohen, J.L., & Robb, C.W. (2020).
Journal of Cosmetic Dermatology, 19(2), 270-277.

https://pubmed.ncbi.nlm.nih.gov/31904191/

The Use of Hypochlorous Acid Lavage to treat Infected Cavity Wounds.

Wongkietkachorn, A., Surakunprapha, P., Wittayapairoch, J., Wongkietkachorn, N., & Wongkietkachorn, S. (2020)
Plastic and Reconstructive Surgery - Global Open, 8(1), e2604.

https://pmc.ncbi.nlm.nih.gov/articles/PMC7015588/

Effects of Hypochlorous Acid Solution on Venous Leg Ulcers (VLU): Experience with 1249 VLUs in 897 Patients.

Bongiovanni, C.M. (2014).
Journal of the American College of Clinical Wound Specialists, 6(3), 32-37

https://pubmed.ncbi.nlm.nih.gov/27104143/

Hypochlorous Acid as a Potential Wound Care Agent: Part II. Stabilized Hypochlorous Acid: Its Role in Decreasing Tissue Bacterial Bioburden and Overcoming the Inhibition of Infection on wound Healing.

Robson, M.C., Payne, W.G., Ko, F., Mentis, M., Donti, G., Shafii, S.M., & Bassin, M. (2007).
Journal of Burns and Wounds, 6, e6.

https://pubmed.ncbi.nlm.nih.gov/17492051/

Salvage of Infected Orthopedic Hardware With Intraoperative and Postoperative Hypochlorous Acid Instillations.

Clayman, E., Dial, K. (2023).
ePlasty, 23, e24.

https://pubmed.ncbi.nlm.nih.gov/36741350/

Hypochlorous acid in a double formulation (liquid plus gel) is a key prognostic factor for healing and absence of infection in chronic ulcers. A nonrandomized concurrent treatment study.

Herruzo R, Fondo Alvarez E, Herruzo I, Garrido-Estepa M, Santiso Casanova E, Cerame Perez S.
Health Sci Rep. 2023 Oct 25;6(10):e1497. doi: 10.1002/hsr2.1497. eCollection 2023 Oct. PMID: 37900091

https://pubmed.ncbi.nlm.nih.gov/37900091/

Antimicrobial efficacy, mode of action and in vivo use of hypochlorous acid (HOCl) for prevention or therapeutic support of infections.

Rasmussen et al. (as cited in Boecker D, Zhang Z, Breves R, Herth F, Kramer A, Bulitta C.
GMS Hyg Infect Control. 2023 Mar 27;18:Doc07. doi: 10.3205/dgkh000433.)

https://pubmed.ncbi.nlm.nih.gov/37034111/

In Vitro and In Vivo Antimicrobial Activity of Hypochlorous Acid against Drug-Resistant and Biofilm-Producing Strains.

Palau M, Muñoz E, Lujan E, Larrosa N, Gomis X, Márquez E, Len O, Almirante B, Abellà J, Colominas S, Gavaldà J. Microbiol Spectr. 2022 Oct 26;10(5):e0236522. doi: 10.1128/spectrum.02365-22. Epub 2022 Oct 3. PMID: 36190408.

https://pubmed.ncbi.nlm.nih.gov/36190404/

Topical hypochlorous acid (HOCl) blocks inflammatory gene expression and tumorigenic progression in UV-exposed SKH-1 high risk mouse skin.

Jandova J, Snell J, Hua A, Dickinson S, Fimbres J, Wondrak GT. Redox Biol. 2021 Sep;45:102042. doi: 10.1016/j.redox.2021.102042.
Epub 2021 Jun 11. PMID: 34144392.

https://pubmed.ncbi.nlm.nih.gov/34144392/

Evaluation of Decontamination Efficacy of Electrolytically Generated Hypochlorous Acid for the Vesicating Agent: A Multimodel Study.

Sharma AK, Shukla SK, Kalonia A, Shaw P, Khanna K, Yashavarddhan MH, Gupta R, Bhatnagar A.
Curr Pharm Biotechnol. 2022;23(2):287-299. doi: 10.2174/1389201022666210311140922.

https://pubmed.ncbi.nlm.nih.gov/33719970/

Treating Chronic Wounds With Hypochlorous Acid Disrupts Biofilm.

Robson MC.
Adv Wound Care (New Rochelle). 2020 Nov;9(11):599-600. doi: 10.1089/wound.2020.1264. Epub 2020 Sep 16. PMID: 33124922.

https://farmaso.com/wp-content/uploads/2022/01/Treating-Chronic-Wounds-with-Hypochlorous-Acid.pdf

Hypochlorous Acid: A Review.

Block MS, Rowan BG.
J Oral Maxillofac Surg. 2020 Sep;78(9):1461-1466. doi: 10.1016/j.joms.2020.06.029. Epub 2020 Jun 25. PMID: 32653310.

https://pubmed.ncbi.nlm.nih.gov/32653307/

Microbicidal Effect of Weak Acid Hypochlorous Solution on Various Microorganisms.

Ono T, Yamashita K, Murayama T, Sato T.
Biocontrol Sci. 2012;17(3):129-33. doi: 10.4265/bio.17.129. PMID: 23007096.

https://pubmed.ncbi.nlm.nih.gov/23007104/

Topical stabilized hypochlorous acid: The future gold standard for wound care and scar management in dermatologic and plastic surgery procedures.

Gold MH, Andriessen A, Bhatia AC, Bitter P Jr, Chilukuri S, Dailey RA, Downie JB, Friedlander SF, Goldberg DJ, Goldman MP, Green JB, Ibrahim SF, Jacob C, Jones CE, Kaufman-Janette J, Lain T, Lupo M, Martin G, Narurkar V, Schlessinger J, Shamban A, Werschler WP, Webb C.
J Cosmet Dermatol. 2020 Feb;19(2):270-277. doi: 10.1111/jocd.13280. Epub 2020 Jan 14. PMID: 31951094.

https://pubmed.ncbi.nlm.nih.gov/31904191/

Paid GLP Report - ISO Guinea Pig Maximization Sensitization Test